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Related Questions
effects on survival of bap1 and pbrm1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation.
Answers
A high-risk BAP1-mutant group and a favorable PBRM1-mutant group have been identified as mutation-defined subgroups of clear-cell renal cell carcinoma with differing clinical outcomes.
Why is the PBRM1-mutant group more advantageous and the BAP1-mutant group more risky?Different clinical behaviors are displayed by clear-cell renal-cell carcinomas. However, it is unknown what molecular genetic processes underlie these behaviors. We found that PBRM1 and BAP1 mutations are largely mutually exclusive and that BAP1 is mutated in roughly 15% of clear-cell renal-cell carcinomas.
145 patients from the University of Texas Southwestern Medical Center in the United States who had primary clear-cell renal cell carcinoma and known PBRM1 and BAP1 mutation status were evaluated between 1998 and 2011 for this retrospective investigation. We used The Cancer Genome Atlas (TCGA second )'s independent cohort (n = 327) for validation.
Those with BAP1-mutant tumors had considerably lower median overall survival in the UTSW cohort than patients with PBRM1-mutant tumors. Despite being rare (three in the UTSW cohort and four in the TCGA cohort), patients with mutations in both PBRM1 and BAP1 had the lowest overall survival.
These findings lay the groundwork for a molecular genetic classification of clear-cell renal cell carcinoma that may have an impact on future treatment choices.
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what are the four things that zonation results from?
Answers
Answer: Temperature, Wind exposure, Environmental, and light intensity. Hope this helped :)
the synthesis of the three fundamental polymers of life, dna, rna and protein, is template-directed. this means that:
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The synthesis of the three fundamental polymers of life, dna, rna and protein, is template-directed. this means that one by one, the monomers are put together according to the order that an existing polymer specifies.
What is central dogma of life?The fundamental tenet of molecular biology explains how genetic information moves from DNA to RNA to produce a protein, a useful end product.According to the core dogma, RNA acts as a messenger to transport the information from DNA to the ribosomes, where it is used to produce all of our proteins.In the cell, the ribosomes work as factories where information is "translated" from a code into the usable component.Gene expression is the process by which the DNA instructions are translated into the functional result.Transcription and translation are the two essential phases of gene expression.Learn more about the central dogma of life with the help of the given link:
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what is energy releasing equation ?
Answers
Answer:
I hope this helps you
Explanation:
ADP is combined with a phosphate to form ATP in the reaction ADP+Pi+free energy→ATP+H2O. The energy released from the hydrolysis of ATP into ADP is used to perform cellular work, usually by coupling the exergonic reaction of ATP hydrolysis with endergonic reactions.
The energy releasing equation, also called enthalpy is calculated using the formula: ΔH = Hfinal - Hinitial
What is enthalpy?Enthalpy refers to the heat content of a system combining the energy of the system with the product of its pressure and volume. When a chemical reaction or physical process occurs energy is emitted in the form of heat.
The equation used to determine the amount of heat released by a system during a reaction or physical process is known as the energy release equation.
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Augusto is a farmer who encounters several bones while plowing his field and wants to know if the bones are human. Which type of anthropologist should he call?.
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Augusto should call a physical anthropologist to know if the bones he encountered on his farm are human bones.
Who is an anthropologist?An anthropologist is a person versed in the holistic scientific and social study of humanity, mainly using ethnography as its method.
Anthropologists study the origin, development, and behavior of humans by examining the cultures, languages, archeological remains, and physical characteristics of people in various background.
According to this question, Augusto is a farmer who encounters several bones while plowing his field.
However, to know if these bones are human's, Augusto should call a physical anthropologist because they deal with the evolution of humans, their variability, and adaptations to environmental stresses.
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class mammalia includes all __________ animals of the phylum chordata that have hair and feed their young with milk. This is giraffe classification. I'm sorry I don't know the subject.
Answers
Answer:
vertebrate
Explanation:
12. glycogen phosphorylase is activated in vigorously active muscle without significant changes in intracellular [camp]. explain.
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glycogen phosphorylase is activated in vigorously active muscle without significant changes in intracellular [camp].
phosphorylase kinase is activated by increased concentrations of Ca 2+ or by the phosphorylation by cAMP dependent protein kinase A .
What is the role of glycogen phosphorylase ?The main role of Glycogen Phosphorylase is to provide phosphorylated glucose (G-1-P) which can be metabolize in glycolysis and produce ATP for the cell.
This phosphorylated glucose comes from glycogen and cellular phosphate, Glycogen is a polymer of non-phosphorylated glucose molecules.
Glycogen phosphorylase is an therapeutic target for type 2 diabetes which show great influence on blood glucose levels through the glycogenolysis pathway.
It acts on the reaction at the initiation of glycogen degradation, where glucose can be produced from glycogen. Glycogen phosphorylase causes phosphor clastic cleavage into glycogen, and produces glycogen-1-phosphate.
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Which of the following options BEST describes the conditions present in the origins of planet Earth?
The oceans of early Earth contained complex organic molecules that formed simple inorganic molecules over time.
Earth's early atmosphere contained oxygen but no ozone and high amounts of UV radiation.
Before cyanobacteria, Earth's early atmosphere had high amounts of UV radiation, no ozone layer and no oxygen.
Protists were the first organisms that evolved and provided oxygen for the atmosphere.
Answers
Before cyanobacteria, Earth's early atmosphere had high amounts of UV radiation, no ozone layer and no oxygen.
Incidence without oxygen in the atmosphere as well as the ozone layer, UVC and UVB levels would be extraordinarily high, requiring life to exist in dimly lit, gloomy surroundings. The development of photosynthesis led to the formation of the ozone layer and boosted atmospheric levels of free oxygen.
Cyanobacteria- Photosynthesis is carried by by the cyanobacteria taxon of microbes. They are not algae, despite the fact that they were once referred to as blue-green algae. It belongs to the phylum of bacteria and includes over 1500 distinct species. According to the endosymbiont theory, cyanobacteria are the ancestors of chloroplasts (plastids). Their DNA profile demonstrates this.
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Is the force per unit area exerted on a blood vessel wall by the blood, and it fluctuates with the alternating contraction and relaxation of the ventricles.
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The force per unit area exerted on a blood vessel wall by the blood is called blood pressure.
In the human body, the circulating blood applies pressure on blood capillaries.
This blood pressure is the amount of force applied by the heart to pump blood across the body.
The heart is an important organ because it collects and delivers blood to all parts of the body through the blood circulatory system.
However, increased blood pressure can also be caused due to hypertension.
Changes in blood pressure can result from various factors such as daily activities, diet imbalance, and lack of physical activity.
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Where do you find the x axis
Answers
Answer:
An x-axis is one of the axes of a two- or three-dimensional graph. The x-axis is the horizontal plane of a graph in a Cartesian coordinate system, which gives a numerical value to each point along the horizontal x-axis, as well as the vertical y-axis (in a two-dimensional graph).
Explanation:
X-axis is the line where the values of y-coordinate are zero for all the values of x. Then the data points for the x-axis are: (1,0), (-1.5, 0) Therefore the equation of the x-axis is y = 0, and its graph on the x and y graph chart is shown below.
Answer:
A coordinate grid has two perpendicular lines, or axes (pronounced AX-eez), labeled just like number lines. The horizontal axis is usually called the x-axis. The vertical axis is usually called the y-axis. The point where the x- and y-axis intersect is called the origin.
Explanation:
In a single-celled organism, mitosis is used for
Your answer:
A. development.
B. reproduction.
C. growth.
D. repair.
Answers
Answer:
B, Reproduction
Explanation:
........................
Mitosis is the process by which all eukaryotic organisms, such as algae and aquatic plants, reproduce. One cell splits into two cells during the process of mitosis. Thus, option B is correct.
What is the importance of mitosis in Reproduction?Multicellular creatures depend on mitosis to produce new cells for growth and to replace damaged or worn-out cells, such as skin cells.
Mitosis serves as the main asexual reproductive mechanism for many single-celled organisms.
Mitosis is a typical and significant method of asexual reproduction in unicellular (single-celled) organisms.
It also goes by the name of binary fission and is a component of the related process known as multiple fission. When an organism undergoes mitosis, it duplicates itself exactly.
Therefore, In a single-celled organism, mitosis is used for reproduction.
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What part of the plant performs sexual reproduction?
Leaves
Flower
Roots
Stem
Answers
Answer:Flower
Explanation:
Halp meh plzzz, idk the answer....
Answers
Answer:
production of blood cells is called
hematopoiesis
Help pleaseeeee
A patient has a severe bacterial infection. within a few weeks of treatment with an antibiotic, the bacterial population consists entirely of
antibiotic-resistant bacteria. How can this outcome most likely be explained?
OA The antibiotic caused a mutation in the bacteria's RNA,
OB. The bacteria began reproducing at a faster rate than before the antibiotic treatment.
Oc. The antibiotic created resistance in the bacteria, and the bacteria are passing the resistance to one another.
oDA Small population of antiblotic-resistant bacteria were present before the treatment, and natural selection increased their
frequency.
Answers
Answer:
D
Explanation:
The antibiotics are targeting bacteria that are not resistant to the antibiotic and any that are will survive treatment. Bacteria can reproduce and share their resistance quickly.
Label the transverse wave below
Answers
Most of the animals in existence today had their origins during the:
A. Mesozoic Era
B. Cambrian Period
C. Cretaceous Period
D. Devonian Period
Answers
Answer:
answer is B
Cambrian period
Answer:
the answer is b
Explanation:
Based on your understanding of Darwin's Theory of Evolution, which of the following species would be the most likely to not evolve?
A)Species 3reproduces through the process of cloning and lives in unstable but mitigates this using advanced technology
B)All three of these species would evolve over time according to Darwin's Theory of Evolution Species
C)1reproduces sexually lives in an ecosystem with a climate that changes every 1,000 yearshas limited resources , and does not use technology
D)Species 2reproduces asexually but shows variation in offspring due to mutations lives in stable ecosystem with abundant resources , and does not technology
Answers
Based on the understanding of Darwin's Theory of Evolution, the statement species reproduce through the process of cloning and live in unstable but mitigates this using advanced technology would cause the species to most likely not evolve (Option A).
What is evolution theory?The evolution theory proposed by Darwin postulates that differential survival and reproduction of individuals leads to change and selection of the fittest phenotypes.
In conclusion, Based on the understanding of Darwin's Theory of Evolution, the statement species reproduce through the process of cloning and live in unstable but mitigates this using advanced technology would cause the species to most likely not evolve (Option A).
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Select each correct answer. More than one answer may be correct.
Which of the following affects the force of gravity between two objects?
the objects' volumes
the distance between the objects
the objects' densities
the objects' masses
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Answer:
I think it's A and D
Explanation:
Answer:
number 2 and number 3
Explanation:
high mass stars include what ?
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Answer:
High mass stars have very high-core temperatures, crushing stellar-core pressures, and are very big and very bright.
Explanation:
A few brown beetles left their population (the first population) and migrated to a population of green beetles (the second population). Which of the following occurs as a result?
Answers
If gene flow occurs between both populations, then genetic variability between populations will decrease, and variability within the second population will increase. Brown beetles introduce new genetic charge to the second population.
What is gene flow?
Gene flow is an evolutive force, together with natural selection and genetic drift.
Gene flow occurs in populations that express migration. This is, individuals from one population migrate to the other and vice versa.
For gene flow to occur, migration is not enough. Successful mating events must also occur, through which individuals from one population get to mate with individuals with the other population, and produce fertile offspring.
This is how the following generations will get genes from both populations.
Gene flow has the opposite effects of genetic drift.
It increases variability within each populationIt reduces genetic heterogeneity between populations
Different populations experiencing gene flow tend to be genetically more similar because they are interchanging genetic material.
Note: Since I could not find the complete question with the options, I will propose the result of the exposed situation.
The exposed situation of a few brown beetles leaving their population and migrating to another population of green beetles might be an example of gene flow.
If this is the case, once in the second population, brown beetles will mate with green beetles and produce new generations with a gene mixture.
Genetic variability between the first and second populations will decrease, and variability within the second population will increase.
Brown beetles introduce new genetic charge to the second population.
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Identify and explain if cloning is a form of asexual reproduction or sexual reproduction.
Answers
Answer:
asexual
Explanation:
Why is revision an important part of the engineering process? Explain and tie in any experience you have had inside or outside of class.
plss help me with thiss plsssss
Answers
Revision is an important part of the engineering process because it helps to record the status of the object at that particular day before they are dent out to other people.
What is Engineering?This is a field which is characterized by the use of scientific knowledge in other to build machines, structures etc. These are used to solve different types of problems and help to make work easier.
Engineering comprises of different processes such as revision and it is important because it helps to take a picture of the history of the product at the particular day and time in which it was sent out for testing.
This helps to eliminate many mistakes and arguments and save people from litigation as a result of the differences in the product should in case it was manipulated and detected when it was returned.
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in what mitosis stage does the cell divide in two.
Answers
Answer:
The stage of mitosis in which the cell divides in two is at the end of the telophase, through a process called cytokinesis.
Explanation:
Telophase is the final stage of mitosis and implies completion of cell division, in which the cellular structures are distributed and take their rightful place in each daughter cell.
In the telophase stage, the mitotic spindle also disappears, the cell nucleus has divided and distributed for each cell and the process of restructuration of cell membranes and endomembrane systems begins.
When the daughter cells are ready, cytokinesis occurs, with the distribution of the cytoplasm and each daughter cell is independent, surrounded by its respective cell membrane.
Traits depend upon heredity true or false
Answers
Answer:
Physical traits yes, personality traits false. Just depends on what type of traits.
Explanation:
Hope this helps!!
When compared to eukaryotic cells prokaryotic cells are almost always- Answers (Smaller) (More complex) (Less rounded) (Faster)
Answers
Answer:
Smaller.
Explanation:
Prokaryotes are a lot smaller than eukaryotes. So this answer may be correct.
Which type of wave can scientists study the
path of to find clues about what materials or
gaps lay deep underground?
A. seismic wave
B. visible light wave
C. tidal wave
Answers
Answer:
A: seismic wave
Explanation:
visible light couldn't penetrate the ground, and a tidal wave is from a tide in the ocean so I doubt it'd be any help to find what materials or gaps plus (correct if wrong) I don't think they've made any instruments to track tidal waves, but they do have seismometers
development and implementation of the next generation sequencing to detect known and novel gene defects
Answers
Implementation of next-generation sequencing to detect known and novel gene disorders.
To conquer those demanding situations, we designed an exon sequencing array to target known and candidate genes using Agilent capture. finally, DNA samples from households, along with sufferers with regarded mutations were sequenced with the use of the Illumina Genome Analyzer. Specific filtering approaches have been implemented to pick out the genetic disorder.
The most in all likelihood ailment-causing versions were analyzed by means of Sanger sequencing. Co-segregation and sequencing analysis of managed samples tested the pathogenicity of the discovered variations.
The phenotype of the patients covered retinitis pigmentosa, congenital stationary nighttime blindness, quality ailment, early-onset cone dystrophy, and Stargardt disease. In control samples with recognized genotypes, NGS detected the expected mutations.
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Students observed a plant left by a window over several days. The plant was watered daily. After three days, the plant began to grow towards the window.
Why is the plant growing towards the window?
Heat from the Sun caused the plant to grow towards the window.
⊝
The plant is leaning towards the window to get fresh air.
⊝
The plant is responding to the stimulus of sunlight.
⊝
The plant is responding to water in the air and growing towards it.
Answers
Answer:d
Explanation:
A.
Heat from the sun is the reason plants grow towards the window if they are inside.
Hope this helps
pollak an, mccarthy ml, bess rs, agel j, swiontkowski mf. outcomes after treatment of high-energy tibial plafond fractures
Answers
A pilon fracture is a specific kind of break that affects the weight-bearing area of the ankle joint and develops at the base of the tibia (shinbone).
Few researchers have looked at the functional and long-term health effects of tibial plafond, or pilon fractures, despite the fact that many have recorded clinical outcomes and consequences related to these fractures. The goal was to study the patient, injury, and treatment factors that affect outcome as well as the midterm health, function, and disability following pilon fractures. Pilon fractures can have disastrous effects on a patient's health and well-being even three years after the accident. These bad results appear to be influenced by a number of social, demographic, and therapeutic factors.Learn more about the fractures with the help of the given link:
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since i have a god complex i willl give 46 points becasue i am a good god
Answers
Answer:
XD THX!
Explanation: