reversing the new oral anticoagulants with prothrombin complex concentrates (pccs): what is the evidence?

Answers

Answer 1

Newer oral anticoagulants offer quite a few benefits over usual dealers (e.g. warfarin), however, they are nonetheless related to bleeding risk and currently, there is no validated reversal remedy for them. While there is a little guide for the use of sparkling frozen plasma, and restrained information handy on the outcomes of activated recombinant factor VII, preclinical statistics advocate that prothrombin complicated concentrates (PCCs) can also have possible in this setting. PCCs are presently used to successfully reverse warfarin-induced anticoagulation; however, scientific proof for their use with new oral anticoagulants is lacking, with most of the accessible records coming from preclinical animal studies. Furthermore, there appears to be variation in the capability of different PCCs to reverse the coagulopathy brought about by way of the new anticoagulants, and a lack of correlation between the reversal of laboratory check consequences and the reversal of anticoagulant-induced bleeding. Although there have been encouraging results, care must be taken in generalizing findings from animal fashions and nonbleeding human subjects to the state of affairs in bleeding patients. Ultimately, more evidence supporting anticoagulation reversal for new anticoagulants is needed, specifically related to the remedy of bleeding in human patients in a scientific setting. According to the present-day evidence, the use of PCCs can also be considered a sensible strategy in dire scientific situations; however, a consensus has not yet been reached concerning PCC use or dosing, due to lack of scientific data.

Anticoagulants are drug treatments that assist prevent blood clots. They're given to humans at a excessive threat of getting clots, to limit their probabilities of growing serious stipulations such as strokes and heart attacks. A blood clot is a seal created through the blood to stop bleeding from wounds.

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Related Questions

hi! hope youe doing ok! can you help me please?

Answers

Answer:

3rd one

Explanation:

3rd one

Answer:

Mutations lead to

Explanation:

I need help with this

Answers

TGCAATTGTGAGGCT is the complementary strand

NEED THIS ASAP, ITS A FINAL!!! WILL MARK BRAINLIEST IF CORRECT.
The following chart shows the amount of four different minerals found in lake water and in the cytoplasm of algae:

Which mineral(s) did the algae uptake through active transport?

Calcium and sodium
Nitrogen and potassium
Nitrogen only
Potassium and sodium

Answers

Answer:

Calcium and sodium

Explanation:

Answer: Calcium and sodium

Explanation:Here is the chart

For the following DNA strand,GTACGATATCGG, select the correct m-RNA sequence. need help ASAP pls!.

Answers

Explanation:

c a u g c u a u a GCC

A male shark has 40 chromosomes in each of its sex cells. How many would be present in its body cells?​

Answers

Answer:

80 sex cells would be present in its body cell

If a male shark has 40 chromosomes in each of its sex cells, then the number of chromosomes that would be present in its body cells is 80.

What are Chromosomes?

Chromosomes may be defined as thin, thread-like structures that appear during the process of cell division. Chromosomes are typically found in the nucleus in the form of chromatin thread and these threads are made up of DNA, RNA, histones, etc. Chromosomes were first discovered by E. Strasburger in 1875.

It is a significant feature of the germ cells or sex cells that they usually contain half the chromosomes in their cells as compared to the normal body cells. These types of cells undergo meiosis.

The half number of chromosomes from each parental cell is successfully fused in order to produce an organism that has normal chromosomes.

Therefore, there are 80 chromosomes that are present in the body cells of a male shark if it has 40 chromosomes in each of its sex cells.

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Which best compares self-renewal and differentiation?

Answers

Answer:  Only differentiation creates greater of the same sorts of cells. Only self-renewal creates extra of the identical sorts of cells. Only self-renewal relies upon on gene expression.

Explanation:

hope this helps

The glands of the body are under control of which system?

Group of answer choices

endocrine

muscular

nervous

skeletal

Answers

Answer:  Endrocrine would be the correct answer. Hope this helped!

alcoholic ketoacidosis causes which effect? a. gluconeogenesis is initiated. b. insulin activity is increased. c. glucagon production is decreased. d. glycogen stores are used.

Answers

Glycogen which are produced during the process is stores and used as because of the alcoholic ketoacidosis

Alcoholic ketoacidosis is the specific group of the symptoms and the metabolic state related to the alcohol use. Symptoms often which include the abdominal pain, vomiting, agitation, the fast respiratory rate, and the specific "fruity" smell. the Consciousness is generally the normal. Complications that may include the sudden death. Alcoholic ketoacidosis is also caused by the combined effects of the alcohol and the starvation on the glucose metabolism; it is characterized by the hyperketonemia and elevated anion gap metabolic acidosis without the significant hyperglycemia.

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which term is used to describe the histologic characterization of tumor cells? group of answer choices staging grading cachexia angiogenesis

Answers

Grading is the term that is used for histologic characterization of tumor cells.

The grading of a tumor cell helps us understand the severity of the tumor. If a cell looks more normal, then this will means that the tumor is not in such a bad condition. However, if the grading shows that the cells are more abnormal, then the condition will be more severe. In this way, grading is used for the histologic characterization of tumor.

To grade a tumor, a doctor will have to perform a biopsy in order to obtains tissues from the specific area of the body. The values for grading a tumor are X, 1, 2, 3, or 4.

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Write a food chain using mouse, seed, snake.

Answers

(going from top to bottom)

snake, mouse, seed

bottom to top

seed, mouse, snake

3. Melting
occurs when a solid substances changes into a liquid phase.
b) False
a) True Los

Answers

Answer:

True

Explanation:

When a metal or another solid object is melt it changes from a solid phase into a liquid phase.

Answer:true

Explanation

Melting  occurs when a solid substances changes into a liquid phase:

true

Which career combines DNA technology and medicine?
pharmaceuticals
paternity testing
environmental studies
biopesticide development

Answers

The pharmaceuticals combines the DNA tachnology and medicine.

Hope I’m right..

Based on the options given, the career combines DNA technology and medicine is Pharmaceuticals

What is DNA technology?

DNA technology refers to the processes which involves the use and manipulation of DNA of living organisms to produce desirable products.

DNA technology is employed in agriculture, environment studies and, pharmaceuticals and medicine.

What is medicine?

Medicine refers to the discipline which deala with health and promoting health by providing care and drugs to enhance health.

Pharmaceuticals is a branch of medicine.

Therefore, the career combines DNA technology and medicine is Pharmaceuticals.

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Water is important to plant cells because it is used as one of the reactants in the process of photosynthesis. What is another reason why water is important to plant cells?

Answers

Answer:

Water helps to maintain turgidity in plant cells.

Turgidity can be defined as the amount of water that is required to make water to exert internal force from inside the plant cell. This is called as turgor pressure it exerts the pressure on the plasma membrane against the cell wall. This process maintains the rigidity inside the plant cell and cells exert external turgor pressure on the neighboring cells that creates a tension, which allows plants to stand erect. Without the amount of appropriate water, the plant cells will collapse and plants will be wilted.  

Therefore, water helps to maintain turgidity in plant cells is an important property of plant cells.

Explanation:

Brainliest please?

Please help me please

Answers

Answer:

Okay just think about the question and what it's asking you. Don't overthink it. If you're still confused i'll put the answer in the comments

Explanation:

The Hallelujah Mountains can float because of Pandora's vast magnetic fields and they are made of what element?

Answers

Answer:

On Pandora, huge outcroppings of unobtanium rip loose from the surface and float in the magnetic vortices due to the Meissner Effect.

Explanation:

Good to see another (Disney's) Avatar-fan!!!  ;)

3. A group of students conducted an experiment to study the growth of
bean plants. An equal number of bean plants of similar size were
planted in containers A and B. Each day for five days, Container A
received water only, while Container B received an equal amount of
weak fertilizer solution. The table below shows the average height of the
plants in each container for each day of the experiment.
Which of these is being tested in this experiment?
A. Effect of water on plant height
B. Effect of fertilizer on plant height
C. Maximum height the plants will grow
D. Number of days the plants will grow

Answers

Answer:

d

Explanation:

i did it before but don't remember how i did it.

This happens when water gets absorbed into the ground and gets stored in the underwater
aquifers.

HELP ASAP

Answers

D, infiltration is the correct answer

what challenges do you think giving expert testimony about dna would have? how would you try to overcome these challenges?

Answers

Answer:

Since DNA evidence is so delicate, chain of custody is important. custody, forensic scientists may not be able to determine who or what contaminated a sample of DNA evidence. I would overcome these challenges by observing proper procedures for storing DNA

Explanation:

Why do you think the structure of the cell membrane allows some materials to enter the cell and denies access to others?​

Answers

Answer:

Being selectively permeable allows the cell to bring in molecules it needs and exclude molecules it does not. It also allows the cell to control when certain molecules move into or out of the cell.

In coastal areas, the large amount of salt in the air and water determines which species can exist there. In these areas, the salt functions as a
A
source of energy
B
growth catalyst.
ОООО
С
limiting factor
D
food source

Answers

Answer:

D

Explanation:

the salt provides for some animals

In the areas where amount of salt in the air and water determines species that can exist the salt functions as a ; ( D ) Foodsource

Meaning of Food source

Given that salt is an essential part of food and the amount of salt in the air and water determines the species located in an area ( coastal area ), the salt in this scenerio will function as a food source responsible for the existence of species.

Hence we can conclude that In the areas where amount of salt in the air and water determines species that can exist the salt functions as a ; ( D ) Foodsource

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What kinds of measurements do meteorologists put on weather maps?

Answers

Answer:  Meteorologists use weather maps to forecast the weather. A HYGROMETER measures the water vapor content of air or the humidity. A WEATHER BALLOON measures weather conditions higher up in the atmosphere. A COMPASS is a navigational instrument for finding directions.

Explanation:

How much work is done on a pumpkin with a force of 16 newtons when you lift it 1.5 Meters?

Answers

Answer:

24J

Explanation:

Given parameters:

Force  = 16N

Height  = 1.5m

Unknown:

Work done  = ?

Solution:

Work done is defined as the force applied on a body to move it through a specific distance.

It is expressed as;

        Work done  = Force x distance

  Now;

      Work done  = 16 x 1.5  = 24J

Hello! I Need help with this. Please Help Make Sure you explain your answer i will be marking brainliest to the first person who has the right answer")

Answers

Answer:

#B

Explanation:

The statement that effects the climate on a nearby land would be west because that current is blowing by Texas with cold temperatures.

The process by which a dead or disabled pathogen (or proteins from that pathogen) is introduced into the body so that an immune response results without an actual infection is called? Group of answer choices Bacteriophage Vaccination/Vaccine Antibiotics Pathogenic

Answers

Answer:

Vaccination/Vaccine

Explanation:

Vaccination/Vaccine: The process of using a dead or weakened version version of a microbe to gain antibodies, thus protecting against future infections without needing to have the disease first.

Bacteriophage: A virus that infects bacteria.

Antibiotics: Medicines are used to treat bacterial infections by killing the bacteria, and do not work on viruses.

Pathogenic: capable of causing disease.

Substance A requires cellular energy to transfer into a cell. While examining a body after death, a forensic scientist finds substance A in the victim's cells. What can the scientist reasonably conclude?

Active transport moved substance A into the cells after death.
Decomposition moved the substance into the cells.
Passive transport moved substance A into the cells.
Substance A moved into the cells before death.

Answers

The correct answer is the last option which states that Substance A moved into the cells before death.

This is because, Substance A requires cellular energy in order to transfer into a cell. This occurs through a process called active transport. Active transport in cellular biology refers to the movement of molecules or ions across a cell membrane against the concentration gradient from a location of lower concentration to a region of higher concentration. Cellular energy is needed for active transport in order to achieve this movement. After death, the chemical reactions that produce energy in the body stop. Hence, this process can only take place when a person is living.The forensic scientist found the same substance A and not it's decomposed constituents in the cell.  Moreover, passive transport cannot take place since Substance A requires energy for transport. So, the other options are incorrect.

Hence, the scientist can reasonably conclude that Substance A moved into the cells before death.

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komori t. the effects of phosphatidylserine and omega-3 fatty acid-containing supplement on late life depression

Answers

Consuming PS (phospholipid) and omega-3 fatty acid supplements, such as Komori T., lowers stress levels, promotes relaxation, and has a beneficial impact on mood.

What are omega-3 fatty acids and phosphatidylserine? Why should people with late-life depression take their supplements?

A phospholipid is PS. The phospholipids in cell membranes play a crucial role. Since PS is involved in cell-to-cell communication and the delivery of biochemical instructions into the cell, which ultimately affects the function of the cell, it is particularly abundant in the brain and nerve cells.

You can obtain omega-3 fatty acids via food or supplements, and they aid in the development and maintenance of a healthy body. They provide energy and support the proper functioning of your immune system, heart, lungs, blood vessels, and other organs.

Particular fish tend to include two important ones, EPA and DHA. Alpha-linolenic acid (ALA), a different omega-3 fatty acid, is derived from plant sources including nuts and seeds.

PS lessens older people's depressive symptoms. In a study, depressed senior participants who took an omega-3 supplement reported a significant improvement in their depressive symptoms. Those who saw the highest benefits also experienced a return to normalization of their increased cortisol levels and circadian rhythms (sleep-wake cycle).

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A prokaryote that obtains both energy and carbon as it decomposes dead organisms.

Answers

A prokaryote that obtains both energy and carbon as it decomposes dead organisms are Heterotroph and Chemotroph.

Heterotrophs are those organisms that feed on other animals and plants and obtain their energy from them. Examples include mammals, snakes, insects, tigers, lions, etc.

Chemotrophs are those organisms that decompose other organisms and obtain their energy by oxidizing the inorganic molecules.

The most common type of organisms that falls into this category is prokaryotes. It includes organisms such as bacteria, fungi, etc.

These organisms release specific enzymes to decompose the dead organism matter and alter its physical state.

They obtain carbon and energy from matter to survive.

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The process of the formation of ATP is known as ______.
a ATP synthase
b photophosphorylation
c chemiosmotic gradient
d electron transport chain

Answers

Answer:

C

Explanation:

chemiosmosis is the answer. hopefully it helped

Answer:

C.

Explanation:

Jacqueline is trying to draw an image of a cell in telophase. Which describes what she should draw?

a cell with chromosomes together in the nucleus
a cell with two distinct nuclei
a cell with chromosomes pulling apart
a cell with chromosomes lined up in the middle

Answers

A cell with two distinct nuclei

Answer:

Explanation:

The cell grows to its full size.

This runner completed a 200-meter race with a time of 23.75 seconds. What was her average speed?

Answers

Answer:

8.4

Explanation:

200/23.75

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Question 7 (1 point)A rebel is known as a person who rises in opposition or armed resistance against an established government or rulerO TrueO False What are three types of body composition? Identify and explain the components of management compensation and the tradeoffs that compensation designers make. Describe the role of wind PLEASE HELP here is 20 points!!! And I mark brainliest! What is the solution set for |s+4| = 6?S=-2 and s=2S=-10 and s= 2O s=-10 and s= 10S-2 and s = 10 Which of the following BEST explains why American leaders formed political parties?a.to end disagreements over policyb.to organize support for their viewsc.to unite farmers and merchantsd.to follow Washingtons advice in his Farewell Address what vehicle component transfers engine torque to the axles allowing the wheels on the same axle to turn at different speeds What was the major restriction on royal authority of the Holy Roman Emperors? A. Attacks from FranceB. PopesC. German BishopsD. Disobedient Barons A student has the following data recorded: final readings: 760. mm Hg, 6.0L, 197 'C. initial readings:712 mm Hg, -76.9 C. She calculates the initial volume to be -2.5 L. Is her answer correct? Explain whyor why not. Error Analysis Find (4) (-5) (-3) . Use pencil and paper. Describe an error you could make that results in the opposite of the correct product. nothing HELPPPP I only have one try left!!PEMDAS!!! Mike has a credit rating of 720. Tyler has a credit rating of 560. Mike and Tyler apply for identical loans from Park Bank. Mike is approved for a loan at 3.2% interest, and Tyler is approved for a loan that charged 3 percentage points higher because of his inferior credit rating. What interest rate is Tyler charged? Winnie Foster is the only child of the people who own the house and the wood?True or False Please Help with this A town's population has been growing linearly since 2000. In 2003 the population was 70100. In2006 the population was 75200.Give the formula for the function P(t), the population t years after 2000.P(t) =Use the formula to find th population in 2008: When should the direct pattern be used to communicate negative nows? 24 hour fitness charges $250 as a registration fee and $15 per month. How much would you pay to be a member of 24 hour fitness for a year? can someone help answer this? ill mark brainliest :) Please answer now!!! Thanks.1) A plumber has a very long piece of pipe that is used to run city water parallel to a major roadway. The pipe is cut into two sections. One section of pipe is 12 ft. shorter than the other. If 3/4 of the length of the shorter pipe is 120 ft., how long is the longer piece of the pipe?.A) 3/4 x - 12 = 120B) 3/4 x = 120C) 3/4 x + 12 = 120D) 3/4(x - 12) = 120.2) Kym switched cell phone plans. She signed up for a new plan that will save her $3.50 per month compared to her old cell phone plan. The cost of the new phone plan for an entire year is $294. How much did Kym pay per month under her old phone plan?.A) 12p - 3.50 = 294B) 12(p - 3.50) = 294C) 12p + 3.50 = 294D) 3.50(p - 12) = 294 a bag of fruit contains 5 apples, 3 pears, and 6 oranges. Toby randomly selects two pieces of fruit, one at a time and does not put them back. What is the probability that the first piece of fruit Toby selects will be an orange and the second piece of fruit will be an apple? need help asapfyi its not 2