Why do second-generation h1 blockers cause less sedation then first-generation h1 blockers?

Answers

Answer 1

Second-generation h1 blockers cause less sedation than first-generation h1 blockers because they do not cross the blood-brain-barrier.

What are H1 histamine receptors?

D-chlorpheniramine (d-CPA) and diphenhydramine are examples of first-generation H1 histamine receptor antagonists that cause sleepiness in people. Presently, they are utilized as over-the-counter sleep aids. Due to their diverse, receptor-independent activities, these H1 histamine receptor antagonists cause sleepiness; nevertheless, the mechanisms underlying these effects are still unknown. Ketotifen, an H1 histamine receptor antagonist of the second generation, is more permeable to the brain than more recent H1 histamine receptor antagonists. In order to access sleep-inducing profiles through H1 histamine receptor blocking actions, the current study evaluated the dose-dependent effects of diphenhydramine and ketotifen on daily sleep-wake rhythms in rats.

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Related Questions

What is it called when the brain deals with overload by simplifying and linking new information to what we already know? schema selective perception heuristics availablity

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Heuristics is the term when the brain deals with overload by simplifying and linking new information to what we already know.

Heuristics is the problem solving ability of the brain. It is a kind of shortcut technique applied by the brain to simplify the large and complex information. This enable to judge or reach to the result in the quickest way possible.

There are good as well as bad effects of heuristics. While it enables a person to solve the problem quickly, it may hinder with the thinking and correct judgement potential of the brain. Therefore heuristics can hamper other cognitive skills of the brain.

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an older adult client experiencing recurrent tension headaches reports taking an over-the-counter (otc) combination of acetaminophen, aspirin, and caffeine several times a week. the nurse should recognize that this combination medication may be contraindicated if the client has a history of what medical condition?

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Gastrointestinal (GI) bleeding is the patient medical condition.

What is Gastrointestinal (GI) bleeding?GI bleeding is a symptom of a disease, not a disease itself.

Hemorrhoids, peptic ulcers, tears or inflammation in the esophagus, diverticulosis and diverticulitis, ulcerative colitis and Crohn's disease, colonic polyps, or cancer in the colon, stomach, or esophagus are just a few of the many potential causes of GI bleeding.

GI bleeding symptoms and signs can either be overtly obvious or covert (occult).

The location of the bleed, which can occur anywhere along the GI tract from the mouth to the anus, and the rate of bleeding determine the signs and symptoms.

GI bleeding frequently stops on its own. If not, the type of treatment depends on where the bleeding originated.

In many instances, a procedure or dose of medication to control bleeding can be administered during some tests.

A bleeding peptic ulcer can occasionally be treated during an upper endoscopy, and polyps can occasionally be removed during a colonoscopy.

In order to reduce stomach acid production in cases of upper GI bleeding, a proton pump inhibitor (PPI) may be administered intravenously.

Your doctor will decide whether you need to keep taking a PPI after determining the cause of the bleeding.

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Mental storge capability to which stimuli in short-term memory can be transferred if they are connected to existing schema and in which information can be stored indefinitely.

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Mental storage capability in short-term memory can be transferred if they are connected to existing schema and in long term memory information can be stored indefinitely.

The term "short-term memory" refers to the memory processes in the brain that are responsible for storing information for brief periods of time, frequently up to 30 seconds.

A sort of "visuospatial" sketch of the information the brain has lately taken in and will later turn into memories is created by short-term memory.

A limitless amount of data can be stored in long-term memory for an infinitely long time. In the hippocampus, a part of the brain, short-term memories are transformed into long-term memories. These long-term memories are kept in the cortex, a different area of the brain.

It is possible that long-term memory has an infinite storage capacity, with availability rather than accessibility serving as the primary restriction on recall.

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What is placed inside the patient when they have an arrhythmia?

Answers

Usually a pacemaker to regulate the rhythm of the patients heart back into normal sinus rhythm

a nurse is educating a pregnant client about obtaining a blood sample for an alpha-fetoprotein (afp) level. which response by the client indicates that the health teaching was successful?

Answers

"If my AFP level is high, it could mean there is a problem with my baby's spinal cord." is the response that indicates that the health teaching was successful.

An high AFP level in a pregnant client may be a sign of a spinal cord defect of some kind. Typically, testing is done between 16 and 18 weeks of gestation, and it calls for follow-up.

The AFP test may need to be repeated because it's a screening tool. A single AFP test cannot ensure that there are no other birth abnormalities. Any abnormal level should be investigated further.

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Question correction:

A nurse is educating a pregnant client about obtaining a blood sample for an alpha-fetoprotein (AFP) level. Which response by the client indicates that the health teaching was successful?

- "If my AFP level is high, it could mean there is a problem with my baby's spinal cord."

-"If my AFP level is negative, it means the baby has no birth defects."

-"If my AFP level is low, then I won't need to follow up."

-"If there is a need to get my AFP level tested, a blood sample will be obtained around 11 weeks."

Which assessment finding in a patient who is prescribed a beta2 agonist would be a reason for the nurse to consult the prescriber?

Answers

The assessment finding in a patient who is prescribed a beta2 agonist would be a reason for the nurse to consult the prescriber is known to be called the option c. unexplained fainting.

What causes someone to pass out?

If a person faint briefly lose consciousness, it is known to be called fainting.

It is seen as a  sudden decrease in regards to blood supply to the brain and that is what causes it. A brief period of unconsciousness is as a result of abrupt reduction in blood pressure.

The alteration in the blood vessels or the heartbeat itself will most likely be the form 0r origin of this quick reduction. Therefore, The assessment finding in a patient who is prescribed a beta2 agonist would be a reason for the nurse to consult the prescriber is known to be called the option c. unexplained fainting.

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Which assessment finding in a patient who is prescribed a beta2 adrenergic agonist would be a reason for the nurse to consult the prescriber?

a. BP 140/90

b. SMBG 165 mg/dL

c. unexplained fainting

d. unexplained tremor

The estimated heritability of 48 percent for neuroticism in the population supports the claim that.

Answers

It supports the claim that (D) the variability in neuroticism is due partly to genetic variability in the population

The degree of neuroticism a person has is a good indicator of their emotional stability. It is occasionally referred as as a negative personality trait characterized by unpleasant emotions, poor self-regulation (an inability to regulate wants), difficulties handling stress, a strong reaction to perceived risks, and a predisposition for complaining.

The IRT-based scores for neuroticism and extraversion were heritable (48 and 49%, respectively) according to a meta-analysis of six twin cohorts with a combined N of 29,496 and 29,501 twin pairs, with a significant amount of the heritability related to non-additive genetic factors.

The extraversion of these genetic factors varies substantially between sexes. The item-response theory method can be applied to any mega- or meta-analytic inquiry that calls for the harmonization of item-based behavioral measurements.

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Question correction:

The estimated heritability of 48 percent for neuroticism in the population supports the claim that

A) the population in general has a recessive gene for neuroticism

B) the incidence of neuroticism is associated with that of another distinct trait

C) those with the neurotic trait share a particular dominant allele

D) the variability in neuroticism is due partly to genetic variability in the population

a nurse is interviewing at an agency owned by a national religious organization that serves homeless and uninsured patients. a large poster display shows a proposed addition that would add 16 beds to the facility that will be funded from profits of the previous 3 years of operation. the nurse recognizes that the agency is most likely what type of agency?

Answers

the answer is : a very good and well agency.
Not for profit of course

The nurse midwife writes in the progress note that the baby is in the occiput posterior presentation. The nurse knows that which maternal position will help facilitate rotation of the fetal head?.

Answers

(B) Hands and Knees is the maternal position that will help facilitate rotation of the fetal head as the baby is in the occiput posterior presentation.

Maternal positioning refers to posture and postures used during pregnancy and labor for comfort, the position of the baby, or to make the process easier.

The fetal head may rotate more easily in this posture (hands and knees), which drags the fetus backward. When a newborn presents in the occiput posterior position, hands-and-knees poses are believed to be particularly helpful.

This is supposed to bring the fetal back forward and improve the fetal head's rotation. Like the upright posture, this one has additional advantages.

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Question correction:

The nurse midwife writes in the progress note that the baby is in the occiput posterior presentation. The nurse knows that which maternal position will help facilitate rotation of the fetal head?

A. Side Lying

B. Hands and Knees

C. Semi-Recumbent

D. Lithotomy

A client is recovering from an ileostomy that was performed to treat inflammatory bowel disease. during discharge teaching, what would the nurse stress the importance of?

Answers

A client is recovering from an ileostomy that was performed to treat inflammatory bowel disease and during discharge teaching, the nurse would stress the importance of increasing fluid intake to prevent dehydration.

Symptoms of inflammatory bowel disease include persistent diarrhea, abdominal pain, rectal bleeding/bloody stools, weight loss, and fatigue.

Purpose of ileostomy is to allow the small intestine or colon to heal once it has been operated on – for instance, if a region of intestine has been removed to treat intestine cancer. to alleviate inflammation of the colon in folks with Crohn's disease or ulcerative colitis to permit for advanced surgery to be applied on the an-us or rectum.

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the nurse is obtaining vital signs for a client and assesses a heart rate of 124 beats per minute. what additional assessment information would be important to obtain that would explain the tachycardia? select all that apply.

Answers

Here are the right additional assessment information:

The client has a temperature of 101.8°F (38.8°C)The client has reports of pain of 8 on a scale of 0 to 10The client just finished ambulating with physical therapy

A rise in heart rate due to an increase in metabolic rate can be brought on by a number of circumstances. Pain, physical activity, fever, drugs, and intense emotions can all cause this.

A blood pressure reading of 120/70 mm Hg does not signify that a patient has just consumed water or that there is a connection to tachycardia. Water would not elevate heart rate, whereas caffeinated beverages would.

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Question correction:

The nurse is obtaining vital signs for a client and assesses a heart rate of 124 beats per minute. What additional assessment information would be important to obtain that would explain the tachycardia? Select all that apply.

The client has been drinking waterThe client has a temperature of 101.8°F (38.8°C)The client has reports of pain of 8 on a scale of 0 to 10The client just finished ambulating with physical therapyThe client has a blood pressure of 122/70 mm Hg

1. Treatment of hypopituitarism is based on the patient’s

Answers

Your doctor will likely perform a number of tests to evaluate your body's hormone levels and look for a reason of hypopituitarism if they have a suspicion that your pituitary hormones are malfunctioning.

Treatment

Medication is frequently the first step in treating hypopituitarism because it can help your hormone levels get back to normal. Because the dosages are chosen to correspond to the levels your body would make if it didn't have a pituitary issue, this is frequently referred to as hormone replacement therapy. The drug can be something you have to take for the rest of your life.

The ability of your body to create pituitary hormones may occasionally fully or partially revert once the ailment causing hypopituitarism has been treated.

And, it uses following medication:

Corticosteroids.

Levothyroxine (Levoxyl, Synthroid, others).

Sex hormones.

Growth hormone

Fertility hormones.

Thus, with the treatment of hypopituitarism patient can cure hormone problems.

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Which is the largest among the followings?

Answers

Answer:

ITS PROBABLY A NUCLEOTIDE

Explanation:

BRAINLEST ME?

the labor and delivery nurse is getting report from the previous shift regarding a client with asian heritage. the departing nurse states that the client did not ask for pain medication because ""asian people can handle pain."" the nurse receiving report understands that this an example of what?

Answers

The nurse receiving the report recognises that the previous shift regarding a client with asian heritage is an example of stereotyping.

Asian Heritage

Asian heritage groups are generally hesitant to seek mental health therapy and may feel awkward when they do. As a result, it is critical to check in with the client both initially and on a regular basis to ensure that they understand the collaborative nature of psychotherapy and are completely engaged. The culturally modified treatment handbook accomplishes this through weekly check-ins and discussion of take-home assignments. South Asian Heritage Month is the name given to the month-long celebration in the South Asian diaspora to celebrate the heritage of people with roots in the South Asian countries of India, Pakistan, Afghanistan, Bangladesh, Sri Lanka, Nepal, Bhutan, and the Maldives.

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the fact that many clinicians view alcoholism as a disease is consistent with the dsm-5's assumption that classification should be based on the model.

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The DSM-5's assumption is that classification should be based on the

medical model.

What is the primary purpose of a classification system such as the DSM 5?

It provides a common language for clinicians to communicate about their patients and establishes consistent and reliable diagnoses that can be used in research on mental disorders.

The DSM-5 method for diagnosing personality disorders is called a categorical approach.

However, an alternative method, called the dimensional approach, is also presented in DSM-5 for consideration and future research.

The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) fifth edition embodies the most recent scientific thinking regarding the criteria content and categorization of mental disorders.

Similar to how the diagnostic standards for numerous specific disorders were improved based on scientific developments,

The manual was reorganized.

The changes can be seen right away in the table of contents, which signals the prevalence of mental disorders worldwide and how different conditions relate to one another.

lifespan, both of which may have an impact on care.

The new framework for the manual's main objectives is to assist clinicians in providing patients with better care by assisting researchers in better understanding the relationships between disorders.

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an orthopedic clinic in a busy metropolitan area would like to improve its patient scheduling process. more specifically, the clinic wants to improve its efficiency and the satisfaction of its patients. the orthopedic clinic plans the change to improve scheduling, and then it carries out a small test of change with three patients on tuesday morning. what’s the next thing the clinic’s improvement team should do?

Answers

The improvement team should measure to see if the change led to improvement.

What is a orthopedic clinic?

The treatment of the musculoskeletal system is the main emphasis of the medical specialty of orthopedics. Muscles, bones, joints, ligaments, and tendons make up this system. An orthopedist is a medical professional with a focus on orthopedics.

The team prepared a test of change, which has now been executed. The group must now analyze the results of the test (the "S" part of the PDSA cycle). They can examine a combination of result and process metrics, such as the frequency with which appointments began on time (such as how satisfied the patients were with the new process).

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After reading your a dependable, hard working individual seeking to combine professional skills and medical education to secure employment within an innovative healthcare organization. What would you want your employer to know about you after reading this part on your resume?

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It should be noted that the thing that you would want your employer to know about you after reading this part on your resume is that the person is experienced for the position.

What is the meaning of a resume?

In order to list their qualifications for a position, job applicants must generate a formal document called a resume. A personalized cover letter that is included with a resume typically conveys interest in a particular position or business and attracts attention to the CV's most crucial details.

In the resume, the person wants to combine professional skills and medical education to secure employment within an innovative healthcare organization. This shows competence.

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Familial hypercholesterolemia is characterized by extremely high levels of cholesterol in the blood, which results from.

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Familial hypercholesterolemia is characterized by extremely high levels of cholesterol in the blood, which results from a mutated gene.

Cholesterol is a steroid fat molecule that occurs naturally in the body. It is essential to the structure of all membranes and is used to synthesize steroid hormones. Certain fatty proteins or lipoproteins in the blood help to transport cholesterol. They are HDL (High Density Lipoprotein) or the 'good' cholesterol, and LDL (Low Density Lipoprotein) or the 'bad' cholesterol.

When excess LDL cholesterol builds up in the blood, it results in hypercholesterolemia. This increases the risk of coronary heart conditions. Anyone with unhealthy lifestyle choices can develop hypercholesterolemia, however when it has a genetic cause, it becomes familial hypercholesterolemia.

Familial hypercholesterolemia is a hereditary condition caused by a mutated gene. This mutated gene prevents the body from removing LDL cholesterol from the blood, leading to an excess build up and high levels of cholesterol. This condition cannot be cured, but with a combination of lifestyle changes and medication, it can be managed.

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steinberg, emma, valenzuea-araujo, doris, zickafoose, joseph, et al. (2016). the "battle" of managing language barriers in health care. clinical pediatrics 55: 1318–1327.

Answers

It is still difficult to provide children with parents who have low English proficiency (LEP) with safe, high-quality healthcare. There aren't many reports on how parents deal with language barriers in healthcare.

In two qualitative interview studies examining the experiences of LEP Latina women receiving pediatric medical care in two urban US cities, we examined sections of 48 interviews with a language barrier focus. We discovered that moms were dissatisfied with their health treatment and that language obstacles were not adequately accommodated. The "battle" of overcoming language barriers, the preference for bilingual providers, the bias against encounters that are interpreted, "getting by" with limited language skills, the fear of being a burden, and stigma and discrimination faced by LEP families are the six themes that emerged as being pertinent to health care across settings.Parents' perspectives shed light on the difficulties in providing appropriate language accommodations in healthcare. To enhance the quality and safety of healthcare for LEP patients and families, it is necessary to work with families to handle language obstacles.

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the power to arrest someone who refuses to undergo treatment for a communicable disease lies with: a community health nurse. a scientist within the nih. a member of the local board of health. a local health officer.

Answers

Local board of health

A client's bun test results are significantly elevated. when reviewing the client's history, which finding is consistent with bun elevation other than renal compromise?

Answers

A client's bun test results are significantly elevated. when reviewing the client's history, we found the client is dehydrated.

A blood urea nitrogen (BUN) test can provide important information about the condition of your kidneys. The major job of your kidneys is to remove waste and extra fluid from your body. If you have kidney illness, the blood may become clogged with these waste particles. In the long run, this could lead to serious health problems like heart disease, anaemia, and high blood pressure.

The BUN test quantifies the urea nitrogen levels in your blood. Your kidneys remove an unwanted substance from your blood called urea nitrogen. Your kidneys may not function properly if your BUN levels are higher than usual.

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a patient with kyphosis has fallen and now complains of​ new-onset neck and back pain with numbness in both arms. regarding spine motion​ restriction, you​ should:

Answers

Tell patient don’t move and get help

the nurse-midwife is performing a pelvic examination on a client who came to her following a positive home pregnancy test. the nurse checks the woman's cervix for the probable sign of pregnancy known as goodell sign. which description illustrates this alteration?

Answers

The nurse-midwife is performing a pelvic examination on a client who came to her following a positive home pregnancy test. The nurse checks the woman's cervix for the probable sign of pregnancy known as goodell sign. The cervix softens illustrates this alteration.

Pregnancy- The period during which a fetus grows within a woman's womb or uterus is known as a pregnancy. When counting from the last menstrual cycle through delivery, a pregnancy typically lasts around 40 weeks, or slightly over 9 months. Pregnancy is divided into three trimesters, as described by healthcare professionals.

Menstrual cycle- The hormone cycle a woman's body is going through every month to get ready for a potential pregnancy is called the menstrual cycle. Between adolescence and menopause, regular menstrual cycles are often an indication that our body is functioning appropriately. Periods that are heavy, painful, or irregular are not typical.

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a nurse is educating a group of nursing students about the molding of the fetal skull during the birth process. what would the nurse include as the usual cause of molding?

Answers

Pressure causes the long head shape at birth

What does the nurse expect to be included in the directions for reconstitution on a drug label? select all that apply.

Answers

The nurse expects to be included in the directions for reconstitution on the drug label.  In order to rehydrate the powder into a liquid form for injection, add 2 mL of sterile water to the vial.

What is the reconstitution process?

Reconstitution is the process of transforming a dried medication into a liquid before administration by combining it with a sterile diluent. The technologies used for reconstitution typically range from vial adaptors to vial-to-vial systems to sophisticated dual chamber reconstitution systems.

According to the label, the fluid's concentration will be 225 mg/mL after the powder is reconstituted with 2 mL of diluent.

The main purpose of sterile water for injectable vials is to reconstitute medicines that are supplied as lyophilized powders. While some medications' prescribing literature may suggest different sterile liquids for reconstitution, the majority stipulate that SW for injection must be used.  

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a nurse is explaining to a pregnant client about the changes occurring in the body in preparation for labor. which hormone would the nurse include in the explanation as being responsible for causing the pelvic connective tissue to become more relaxed and elastic?

Answers

the nurse should include relaxin hormone in the explaination

In order to prepare the mother's pelvis for delivery, the relaxin and estrogen hormones force the connective tissues to become even more relaxed and elastic as well as the joints to become more flexible. The corpus luteum in the ovary secretes relaxin into the bloodstream in females. It is also secreted by the uterine lining, the membranes that surround the fetus, and the placenta during pregnancy. In males, the prostate gland secretes relaxin, which may be present in the semen but is often absent from blood circulation. The female reproductive cycle and pregnancy are the times when the effects of relaxin are most understood. Following ovulation, during the second part of the menstrual cycle, relaxin levels in the blood increase.

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What happens to the placenta in multiple births?

Answers

The placenta in multiple birth contains blood vessels which connect within it and divert blood from one fetus to the other.

What is Placenta?

This is referred to an organ which is produced during pregnancy and it helps to provide adequate oxygen and nutrients to the fetus so as to enable it grow and survive in the womb.It also forms a type of attachment between the mother and the fetus.

In the case of multiple births, the placenta has blood vessels which helps in the diversion of blood from one fetus to another for the adequate supply of nutrients thereby making it the most appropriate choice.

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a client with diabetes received lab results showing a total cholesterol level of 220 mg/dl, hdl 38 mg/dl, and ldl 140mg/dl. which food choice will the nurse encourage the client to avoid as the priority?

Answers

Red meat of courses

the nurse is admitting a primigravida client who has just presented to the unit in early labor. which response should the nurse prioritize to assist the client in remaining calm and cooperative during birth?

Answers

The nurse prioritize to assist the client in remaining calm and cooperative during birth is "Baby is on the way. I'll assist you and explain what's happening."

What is early labor?

The preliminary symptoms of labor are referred to as pre-labor. It is the body's method of preparing for actual labor. False labor has been used to refer to prodromal labor. Although prodromal labor starts out similarly to typical labor, the baby does not actually deliver.

Your likelihood of preterm labor and early delivery is highest if you have the following risk factors: In the past, you gave birth to a premature child. You are carrying several children. You currently have uterine or cervix issues, or you previously did.

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True or false soon after it was introduced, Valium became the top selling perscribed drug in the united states

Answers

True- Valium, approved in the early 1960s, became the top-selling pharmaceutical in the US in the 1970s.
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